Course InformationAims & ObjectivesLearning ResourcesLearning ActivitiesAssessment & GradesPolicies & Guidelines
1. Course Identification
| Course | Pharmaceutical Analysis | |||
| Faculty | Mathematics and Natural Sciences | Study Program | Pharmacy | |
| Code | SFA-217 | Credits | 2 credits | |
| Group | Study Program | Status | Compulsory | |
| Semester | II (Second) | Availability | Limited in Study Program | |
| Learning Method | Class | Media | Blended Learning | |
| Cluster | Biomedical and Pharmaceutical Sciences: Pharmaceutical Chemistry | Prerequisite | – | |
2. Course Description
Pharmaceutical Analysis Course in the Curriculum in Pharmacy Study Program is given to second-semester students with a weight of 2 credits. This subject is a compulsory subject that is taken with Basic pharmaceutical chemistry as prerequisites. This course aims to support the Learning Outcomes in the form of mastery of gravimetric, titrimetric, and UV-Vis spectrophotometric methods and their applications to identified and determination of an analyte in drugs, dosage forms, foods, and cosmetics, as well as knowledge of validation of analytical methods and data analysis.
1. Learning Outcome
| LO Code | LO |
| PEF1 | Able to comprehend the theories, methods and concepts within the scope of pharmaceutical sciences and technologies in the disciplines of pharmaceutics, pharmacognosy, pharmaceutical chemistry and pharmacology as well as their application in pharmaceutical works. |
| PEF6 | Able to comprehend the basic principles of integrating Islamic values within pharmaceutical sciences and practices |
| KKF4 | Able to apply standardized analytical methods for the quality and halal assurance of drugs and cosmetics |
2. Course Learning Outcome and indicators
| Supported LO Code | CLO Code | CLO and indicators |
| PEF1 | CLO1 | Students can identify and quantify analytes with classical methods and UV / Vis spectrophotometry.
Sub CLO1a: Students can calculate analytes in drug, dosage form, food and cosmetic products using classical analytical methods (gravimetry, titrimetry). Sub CLO1b: Students can identify and calculate analytes in drug, dosage form, food and cosmetic products using the UV / Vis spectrophotometry method. 1. Students can calculate the percentage of the mass of the analyte in a mixture of compounds using gravimetric factors correctly. 2. Students can calculate the concentration of analytes using the Lambert-Beer equation correctly. 3. Students can calculate analyte levels based on the correct stoichiometry of analytes and titrants. 4. Students can accurately identify analytes with the UV / VIS spectrophotometric method. |
| CLO2 | Students can design an analytical method validation protocol for determining the concentration of analytes.
1. Students can design validation protocols of analytical methods to determine levels according to compendia correctly. 2. Students can calculate the validation parameters of the analysis method correctly. |
|
| PEF6 | CLO3 | Students can solve problems in analytical methods in pharmaceutical work.
1. Students can analyze the stages of work in Gravimetric, Titrimetric, and UV / Vis Spectrophotometry methods correctly. 2. Students can calculate the preparation of standard and test solutions correctly. 3. Students can provide solutions at critical steps in the gravimetric, titrimetric, and UV / vis spectrophotometry methods |
| KKF4 | CLO4 | Students can evaluate the test results and the analytical methods used.
1. Students can evaluate the test result and analyze the method correctly. |
3. Course Learning Outcome Map Analysis
Primary References
- Christian, GD, 2004, Analytical Chemistry, Sixth Edition, John Wiley and Sons Inc, New York.
- Harris, D.C., 2010, Quantitative Chemical Analysis, Eighth Ed., W.H. Freeman and Company, New York
- Moffat, A.C., Osselton, M.D., Widdop, B., 2011, Clarke’s Analysis of Drugs and Poisons in pharmaceuticals, body fluids and postmortem material, Fourth Ed., Pharmaceutical Press.
- Pavia, D. L., Lampman, G. M., Kriz, G. S., dan Vyvyan, J. R., 2009. Introduction to Spectroscopy. United States: Brooks/Cole Cengange Learning.
- Kompendia (FI, USP, BP)
1. Learning activities (mohon diperhatikan verb menggunakan taksonomi bloom)
| Sesion | CLO | Topic | Learning activities |
| 1 | CLO3 | Contract learning, chemical analysis in our lives.
Chemical analysis in the pharmaceutical field, analysis based on objectives and methods. |
Class:
The lecturer explains the concept map, grading system, references, and class rules, explains the introduction to pharmaceutical analysis. The lecturer gives a quiz at the end of the meeting. Online: The lecturer uploads all learning material. Students download the content and study it. 100 minutes in class Week-4 February 2020 |
| 2 | CLO3 | Basic Concepts of Pharmaceutical Analysis:
Unit of concentration, preparing test solutions, types of weighing, BMTS analytical balance, important figures, glassware for measurement. |
Class:
The lecturer divides the class into small groups, giving different scenarios to be discussed in each group. Small groups are asked to submit and explain the scenarios that have been discussed. The lecturer gives a resume and quiz at the end of the meeting. Online: Students are asked to study the material that has been previously uploaded and work on online quiz for a limited time before the class meeting. Structured Assignment: The lecturer gave the task to find five products of various pharmaceutical dosage form and their composition, and students were asked to calculate how to make a test solution based on FI V for determining the levels of analytes in the product. 100 minutes in class Week-1 March 2020 |
| 3 | CLO4 | Evaluation of test data:
Types of analysis errors, outliers of data. |
Class:
Lecturers provide outliers data scenarios, analyzed together using a laptop. Lecturers give assignments to be done in class. The lecturer provides a resume and feedback on the given assignment. Online: Students are asked to study the material that has been previously uploaded and work on online quiz for a limited time after the class meeting. 100 minutes in class Week-2 March 2020 |
| 4 | CLO1(a)
CLO3 |
Classic analysis technique:
Gravimetry (precipitation, analysis step, coprecipitation) |
Class:
The lecturer divides the class into small groups, giving different scenarios to be discussed in each group. Small groups are asked to submit and explain the scenarios that have been discussed. The lecturer gives a resume and quiz at the end of the meeting. Online: Students are asked to study the material that has been previously uploaded and work on online quiz for a limited time after the class meeting. Structured Assignment: The lecturer gives calculation problems for assignments at home. 100 minutes in class Week-3 March 2020 |
| 5 | CLO1(a)
CLO3 |
Classic analysis technique:
Gravimetry (gravimetric factor, calculation of analytes) |
Class:
The lecturer displays the assignment then asks the designated student to explain the homework that has been done. The lecturer gives feedback on the given assignment and asks students to upload the correct task if there are still errors. Online: Students study lecture material that has been previously uploaded and do homework assignments and then be uploaded in the classroom before the class meeting. 100 minutes in class Week-4 March 2020 |
| 6 | CLO1(a)
CLO3 |
Classical analysis techniques: neutralization titration, complexometry titration | Class:
The lecturer divides the class into small groups, giving different scenarios to be discussed in each group. Small groups are asked to submit and explain the scenarios that have been discussed. The lecturer gives a resume and quiz at the end of the meeting. Online: Students are asked to study the material that has been previously uploaded and work on online quiz for a limited time before the class meeting. Structured Assignment: The lecturer gives calculation problems for assignments at home. 100 minutes in class Week-1 April 2020 |
| 7 | CLO1(a)
CLO3 |
Classic analysis techniques: argentometric titration, redox titration | Online-class:
Lecturers upload lecture material, students pay close attention to the lecture material. Students are given the opportunity of open discussion online. Lecturers provide scenarios for learning during online lectures. Lecturers give online quizzes. Online: Students work on time-limited online quiz questions before online lecture ends. 100 minutes in class Week-2 April 2020 |
| 8 | CLO1(a)
CLO3 CLO4 |
Mid-term examination | 100 minutes in class
Week-3 & 4 April 2020 |
| 9 | CLO1(b) | Electromagnetic radiation and its interaction with matter (absorption of light) | Class:
The lecturer divides the class into small groups, giving different scenarios to be discussed in each group. Small groups are asked to submit and explain the scenarios that have been discussed. The lecturer gives a resume and quiz at the end of the meeting. Online: Students are asked to study the material that has been previously uploaded and work on online quiz for a limited time before the class meeting. 100 minutes in class Week-2 May 2020 |
| 10 | CLO1(b)
CLO3 |
UV-Vis spectrophotometry, chromophores and auxochromes, UV-Vis spectrophotometry instrumentation | Online-class:
Lecturers upload lecture material, students pay close attention to the lecture material. Students are given the opportunity of open discussion online. Lecturers provide scenarios for learning during online lectures. Lecturers give online quizzes. Online: Students work on time-limited online quiz questions before online lecture ends. Structured Assignment: The lecturer gives a homework assignment, the students look for analytical methods using UV-Vis spectrophotometry. 100 minutes in class Week-3 May 2020 |
| 11 |
CLO1(b) CLO3 |
Molar extension coefficient, Lambert-Beer law, derivatization in UV-Vis spectrophotometry, sample preparation. | Class:
The lecturer divides the class into small groups, giving different scenarios to be discussed in each group. Small groups are asked to submit and explain the scenarios that have been discussed. The lecturer gives a resume and quiz at the end of the meeting. Online: Students are asked to study the material that has been previously uploaded and work on online quiz for a limited time before the class meeting. Structured Assignment: The lecturer gives calculation problems for assignments at home. 100 minutes in class Week-1 June 2020 |
| 12 |
CLO1(b) CLO4 |
Spectra identification and quantification techniques (single point calibration and multiple point calibration) | Class:
The lecturer divides the class into small groups, giving different scenarios to be discussed in each group. Small groups are asked to submit and explain the scenarios that have been discussed. The lecturer gives a resume and quiz at the end of the meeting. Online: Students are asked to study the material that has been previously uploaded and work on online quiz for a limited time before the class meeting. 100 minutes in class Week-2 June 2020 |
| 13 |
CLO2 |
Analysis method validation:
Category validation analysis methods, VMA parameters. |
Online-class:
Lecturers upload lecture material, students pay close attention to the lecture material. Students are given the opportunity of open discussion online. Lecturers provide scenarios for learning during online lectures. Lecturers give online quizzes. Online: Students work on time-limited online quiz questions before online lecture ends. Structured Assignment: The lecturer gives a homework assignment to make the draft validation protocol for the analysis method. 100 minutes in class Week-3 June 2020 |
| 14 |
CLO2 |
Design the validation protocol of the analysis method | Class:
The lecturer divides the class into small groups according to the assignment topic the previous day. The lecturer provided a guide for working on the validation protocol using Excel and Office. 100 minutes in class Week-4 June 2020 |
| 15 |
CLO1(a,b) CLO3 |
Case study analysis method | Class:
The lecturer divides the class into small groups to work on case studies. The lecturer evaluates the presentation and gives feedback. Online: Students upload presentation material five days after the lecture. 100 minutes in class Week-1 July 2020 |
| 16 | CLO1(b)
CLO3 CLO4 |
Final examination | 100 minutes in class
Week-2 July 2020 |
2. Learning Experience
Students attend lectures offline synchronously at class, using google classroom media, google form for quiz.
1. Assessment
| CLO Code | Assessment | Weight |
| CLO1 | The assessment uses written assignments and examinations.
The assignment was doing calculation problems in gravimetric, titrimetric, and spectroscopy. |
30% |
| CLO2 | The assessment uses assignments and quizzes.
The assignment is to design a method validation protocol from FI V. |
20% |
| CLO3 | The assessment uses assignments, quizzes, and written examinations.
The assignment is to analyze case studies. |
30% |
| CLO4 | The assessment uses assignments, quizzes, and written examinations. | 20% |
2. Grading and Evaluation Systems
Grading system uses reference assessment as follows:
| Letter Value | Weight | Minimum Value | Value Range |
| A | 4 | 80 | 80.00 – 100 |
| A- | 3.75 | 77.5 | 77.50 – 79.99 |
| A/B | 3.5 | 75 | 75.00 – 77.49 |
| B+ | 3.25 | 72.5 | 72.50 – 74.99 |
| B | 3 | 70 | 70.00 – 72.49 |
| B- | 2.75 | 67.5 | 67.50 – 69.99 |
| B/C | 2.5 | 65 | 65.00 – 67.49 |
| C+ | 2.25 | 62.5 | 62.50 – 64.99 |
| C | 2 | 60 | 60.00 – 62.49 |
| C- | 1.75 | 55 | 55.00 – 59.99 |
| C/D | 1.5 | 50 | 50.00 – 54.99 |
| D+ | 1.25 | 45 | 45.00 – 49.99 |
| D | 1 | 40 | 40.00 – 44.99 |
| E | 0 | 0 | < 40 |
Evaluation Systems
Students must achieve a grade of at least 40 for each course learning outcome. If it does not meet the requirements, they must carry out the test/remedial for the relevant course learning outcome.